We're working to understand how genes are turned on and off by small RNAs, and how these processes contribute to development and fertility.
In the Claycomb Lab, we are fascinated by all forms of gene regulation by small noncoding RNAs. Our current work aims to uncover the molecular mechanisms by which small RNA pathways modulate chromatin to regulate gene expression, and understand how this regulation impacts development and fertility. We use an integrated experimental approach that includes genetics, genomics, biochemistry and cell and molecular biology. Our mighty champion in this research is the nematode, C. elegans, which has long been an outstanding model system to dissect how small RNAs regulate gene expression.